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NBTIs-IN-4

CAT: 0804-HY-132923Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-132923Size:1 Each
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Description
NBTIs-IN-4 demonstrates potent antibacterial activity against diverse Gram-positive pathogens, inhibition of both DNA gyrase and topoisomerase IV, a low frequency of resistance.
CAS Number
2758890-16-1
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nbtis-in-4.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C2=N1)N=CC(F)=C2C[C@@H]([C@@H]3OC[C@H](CO3)NCC4=NN=C5OCCSC5=C4)O
Molecular Formula
C22H24FN5O5S
Molecular Weight
489.52
References & Citations
[1]Lu Y, et al. Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA. J Med Chem. 2021 Oct 28;64 (20) :15214-15249.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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