DDO-8926

• Description :

  DDO-8926 is a potent and selective BET inhibitor that can significantly reduce mechanical hypersensitivity by inhibiting the expression of pro-inflammatory cytokines and reducing excitability for neuropathic pain research[1].

• CAS Number :

  [3017181-08-4]

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ddo-8926.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=NN(C(C)=C1C2=C(C(C3=C4NC=NC4=NC=C3)=CC(NS(CC)(=O)=O)=C2)F)C

• Molecular Formula :

  C20H21FN6O2S

• Molecular Weight :

  428.48

• References & Citations :

  [1]Xuetao Chen, et al. Discovery of 1H-Imidazo[4,5-b]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain. J Med Chem. 2023 Jul 13;66 (13) :8725-8744.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported