DDO-02005

CAT: 0804-HY-144801ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-144801ASize:1 Each
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Description
DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine[1].
CAS Number
[1186049-44-4]
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ddo-02005.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)CNC2CCN(CC3=NC4=CC=CC=C4O3)CC2.[H]Cl.[H]Cl
Molecular Formula
C21H27Cl2N3O2
Molecular Weight
424.36
References & Citations
[1]Zhao L, et al. Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors. J Enzyme Inhib Med Chem. 2022;37 (1) :462-471.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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