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LC-04-045

CAT: 0931-T205286-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T205286-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
MAPK|||Interleukin
Related Pathways
Immunology/Inflammation|||MAPK
Bioactivity
LC-04-045 is a molecular glue degrader (MGD) of NEK7 (NIMA related kinase 7) . This compound effectively degrades NEK7 in MOLT-4 cells, exhibiting a DC50 (half-maximal degradation concentration) of 7 nM and a Dmax (maximum degradation rate) of 90%. LC-04-045 displays high selectivity for NEK7 across the proteome and mediates NEK7 degradation via the ubiquitin-proteasome system (UPS), relying on a degradation motif that includes glycine 57 (G57) in NEK7. Additionally, LC-04-045 effectively inhibits the secretion of IL-1? and IL-18, with IC50 values of 33.03 nM and 32.99 nM, respectively. LC-04-045 is applicable for research in inflammatory diseases.
Molecular Formula
C32H28ClN5O3
Molecular Weight
566.05
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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