LC-04-045

• Target :

  MAPK|||Interleukin

• Related Pathways :

  Immunology/Inflammation|||MAPK

• Bioactivity :

  LC-04-045 is a molecular glue degrader (MGD) of NEK7 (NIMA related kinase 7) . This compound effectively degrades NEK7 in MOLT-4 cells, exhibiting a DC50 (half-maximal degradation concentration) of 7 nM and a Dmax (maximum degradation rate) of 90%. LC-04-045 displays high selectivity for NEK7 across the proteome and mediates NEK7 degradation via the ubiquitin-proteasome system (UPS), relying on a degradation motif that includes glycine 57 (G57) in NEK7. Additionally, LC-04-045 effectively inhibits the secretion of IL-1? and IL-18, with IC50 values of 33.03 nM and 32.99 nM, respectively. LC-04-045 is applicable for research in inflammatory diseases.

• Molecular Formula :

  C32H28ClN5O3

• Molecular Weight :

  566.05

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C