Products for Research Use Only
RegisterLogin

ALKBH5-IN-5

CAT: 0804-HY-172158-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-172158-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ALKBH5-IN-5 (compound 18l) is an ALKBH5 inhibitor, exhibiting highly selective inhibitory effect on ALKBH5 with an IC50 of 0.62 μM. ALKBH5-IN-5 exerts a strong antiproliferative effect on NB4 cells with an IC50 of 0.63 μM. ALKBH5-IN-5 binds with ALKBH5 with a Kd of 804 nM. ALKBH5-IN-5 directly targets ALKBH5 in cells and alters m6A levels on mRNA, blocks the related downstream signal pathways, promotes differentiation, and induces Apoptosis. ALKBH5-IN-5 exerts excellent in vivo antitumor activity with TGITV values of 66.3%[1].
CAS Number
140481-05-6
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Concentration
10mM
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C=C1)N(CCC2=CC=CC=C2OC)C1=O
Molecular Formula
C13H13NO3
Molecular Weight
231.25
References & Citations
[1]Wu H, et al. Discovery of Covalent and Cell-Active ALKBH5 Inhibitors with Potent Antileukemia Effects In Vivo. Angew Chem Int Ed Engl. 2025 Feb 20:e202424928.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-165422-01ALKBH5-IN-3
HY-148933-01ALKBH5-IN-2
HY-W173146-01ALKBH5-IN-4
HY-P705543-01ALKBH5, Human (His)
HY-P83693-01ALKBH5 Antibody (YA3429, Rabbit)
HY-RS23130Alkbh5 Rat Pre-designed siRNA Set A
HY-RS00606ALKBH5 Human Pre-designed siRNA Set A
HY-RS16695Alkbh5 Mouse Pre-designed siRNA Set A
HY-160457-01FABP4/5-IN-5
HY-1494765-LOX-IN-5

Alternative Products

CatalogName
T203011-01ALKBH5-IN-5
520016-01ALKBH5
abx456407-01RNA Demethylase ALKBH5 (ALKBH5) Antibody
YP-W29932-01Mouse Alk B homologue 5, ALKBH5 (Alk B homologue 5, ALKBH5) ELISA Kit
F54722-0.08MLALKBH5 Antibody
A03360-2Anti-RNA demethylase ALKBH5 ALKBH5 Antibody
GTR19236507-01ALKBH5-IN-2
T201322-01ALKBH5-IN-3
DF2585-BPALKBH5 Peptide

Popular Products