OPB-3206

CAT: 0931-T207397-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T207397-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
166245-54-1
Target
MMP
Related Pathways
Proteases/Proteasome
Bioactivity
OPB-3206 is a selective inhibitor of matrix metalloproteinases (MMPs) . It inhibits stromelysin, collagenase, gelatinase A (MMP-2), and gelatinase B (MMP-9) with IC50 values of 7x10^-7 M, 5x10^-6 M, 5x10^-7 M, and 2x10^-6 M, respectively. OPB-3206 reversibly binds to the zinc-binding site of MMPs, blocking the activation of MMP-9 and reducing the degradation of the extracellular matrix, thereby inhibiting tumor lung metastasis. OPB-3206 shows potential for research in osteosarcoma lung metastasis.
Smiles
O(C)N1C=2C(C[C@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)C1=O)=CC=CC2
Molecular Formula
C18H25N3O5
Molecular Weight
363.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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