LV-320

• Description :

  LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5 ��M and a Kd of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo[1].

• UNSPSC :

  12352005

• Target :

  Atg4; Autophagy

• Type :

  Reference compound

• Related Pathways :

  Autophagy

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/LV-320.html

• Purity :

  95.0

• Solubility :

  DMSO : 135 mg/mL (ultrasonic)

• Smiles :

  ClC1=CC2=NC=CC(/C=C/C3=CC=C(C(SCCC(O)=O)SCCC4=CC=CC=C4)C=C3)=C2C=C1

• Molecular Formula :

  C29H26ClNO2S2

• Molecular Weight :

  520.11

• References & Citations :

  [1]Bosc D, et al. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B. Sci Rep. 2018 Aug 3;8 (1) :11653. doi: 10.1038/s41598-018-29900-x.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2449093-46-1]