Products for Research Use Only
RegisterLogin

AMT-562

CAT: 0804-HY-171747-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-171747-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AMT-562 is an antibody-drug conjugate (ADC) consisting of a novel anti-HER3 antibody Ab562 conjugated to the linker MC-VA-PAB and the topoisomerase I inhibitor Exatecan (HY-13631). The ADC toxic molecule and linker portion are MC-VA-PAB-Exatecan (HY-147270). AMT-562 can induce apoptosis and has antitumor activity against pancreatic, esophageal, and gastric cancers[1][2].
UNSPSC
12352203
Target
Antibody-Drug Conjugates (ADCs) ; Apoptosis; EGFR; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
[AMT-562]
References & Citations
[1]Weng W, et al. AMT-562, a Novel HER3-targeting Antibody-Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors. Mol Cancer Ther. 2023 Sep 5;22 (9) :1013-1027. |[2]KRAIEM, et al. Treatment of cancer. WO2021151984A1.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
ErbB3/HER3; Topo I

Related Products

CatalogName
HY-163159-01NP3-562
HY-W953606CRBN ligand-562
HY-150014-01AMT-NHS
HY-101251-01AMT (hydrochloride)
HY-101251RAMT (hydrochloride) (Standard)
HY-R01753A-01Hsa-miR-562 agomir
HY-RI01753A-01Hsa-miR-562 antagomir
HY-RI01753-01Hsa-miR-562 inhibitor
HY-R01753-01Hsa-miR-562 mimic
HY-P89043AMT Antibody (YA8727, Mouse)

Alternative Products

CatalogName
T9901A-1039-01AMT-562
GTR18712516-01AMT-562 Antibody
555050-01AMT
BA6106-10NP3-562
JH919883PRAX-562
ABC-TC0208Detroit 562
ABC-TC0487K-562
PC49350FluorN-562®
GTR18172829AMT Antibody
B6480-10AMT hydrochloride

Popular Products