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AMT-562

CAT: 0931-T9901A-1039-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T9901A-1039-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
EGFR, Apoptosis, Antibody-Drug Conjugates (ADCs), Topoisomerase
Related Pathways
Apoptosis, Antibody-drug Conjugate/ADC Related, Tyrosine Kinase/Adaptors, DNA Damage/DNA Repair, JAK/STAT signaling, Angiogenesis
Bioactivity
AMT-562 is an antibody-drug conjugate (ADC) composed of a novel anti-HER3 antibody, Ab562, linked to the linker Mc-VC-PAB and the topoisomerase I inhibitor, Exatecan. The ADC's toxic component and linker are represented as MC-VA-PAB-Exatecan. AMT-562 can induce apoptosis and exhibits antitumor activity against pancreatic, esophageal, and gastric cancers.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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