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NLRP3-IN-77

CAT: 0804-HY-171589Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171589Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLRP3-IN-77 (Compound 7n) is a potent NLRP3 inflammasome inhibitor. NLRP3-IN-77 inhibits the viability of THP-1 cells with an IC50 value of 5.36 nM. NLRP3-IN-77 can effectively reduce the secretion of interleukin-1β (IL-1β) and interleukin-18 (IL-18) . NLRP3-IN-77 is promising for research of diseases related to the abnormal activation of the NLRP3 inflammasome, such as cancer and inflammatory diseases[1].
CAS Number
2924547-57-7
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=S(N1[C@@H](CC2=CC=CC=C2C1)C(NC3=C4C(CCC4)=CC5=C3CCC5)=O)(C6=CC=C(C=C6)N)=O
Molecular Formula
C28H29N3O3S
Molecular Weight
487.61
References & Citations
[1]Albanese V, et al. Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer. J Med Chem. 2023 Apr 13;66 (7) :5223-5241.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; NLRP3

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