DA-1241

CAT: 0804-HY-171454-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-171454-01Size:5 mg
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Description
DA-1241 is a GPR119 agonist. DA-1241 reduces macrophage differentiation through downregulation of NFκB signaling by activating GPR119. DA-1241, alone and in combination with a DPP4 inhibitor, reduces liver inflammation and restores inflammation-related liver gene expression. DA-1241 can be used for the research of metabolic dysfunction-associated steatohepatitis (MASH) [1].
CAS Number
[1914136-10-9]
UNSPSC
12352005
Target
GPR119
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease; Inflammation/Immunology
Concentration
10mM
Purity
99.18
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=NC(C2=C(F)C=C(OCCCC3CCN(C4=NC=C(CC)C=N4)CC3)C=C2F)=NO1)C
Molecular Formula
C25H31F2N5O2
Molecular Weight
471.54
References & Citations
[1]Lee SH, et al. GPR119 activation by DA-1241 alleviates hepatic and systemic inflammation in MASH mice through inhibition of NFκB signaling. Biomed Pharmacother. 2023 Oct;166:115345.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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