CK1δ-IN-9

• Description:

  CK1δ-IN-9 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1δ with IC50 of 1.4 nM. CK1δ-IN-9 inhibits p38α and p38β with IC50 of 0.25 μM and 0.78 μM. CK1δ-IN-9 exhibits pharmacokinetic characteristics with a good oral bioavailability (70%) and a moderate clearance[1].

• UNSPSC:

  12352005

• Target:

  Casein Kinase; p38 MAPK

• Related Pathways:

  Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt

• Field of Research:

  Others

• Smiles:

  FC1=CC=C (C2=NN (C) C=C2C3=C4C=NNC4=NC=C3) C=C1

• Molecular Formula:

  C16H12FN5

• Molecular Weight:

  293.30

• References & Citations:

  [1]McCarver S, et al., Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions. ACS Med Chem Lett. 2024 Mar 7;15 (4) :486-492.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CK1; p38α; p38β

• CAS Number:

  3057263-82-5