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CK1δ-IN-9

CAT: 0931-T205445-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205445-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3057263-82-5
Target
Casein Kinase, p38 MAPK
Related Pathways
MAPK, Stem Cells, Metabolism
Bioactivity
CK1δ-IN-9 (Compound 8) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ with an IC50 of 1.4 nM. The compound also inhibits p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 exhibits favorable pharmacokinetic properties, including high oral bioavailability (70%) and moderate clearance.
Smiles
FC=1C=CC(=CC1)C2=NN(C=C2C=3C=CN=C4NN=CC43)C
Molecular Formula
C16H12FN5
Molecular Weight
293.298
Shipping Conditions
Ice Packs
Storage Temperature
-20°C