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P38 MAP Kinase-IN-1

CAT: 0804-HY-171275Size: 1 EachDry Ice: NoHazardous: No
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Description
P38 MAP Kinase-IN-1 (Compound 4) is the inhibitor for p38, and can be used for inflammation and auto-immune responses related research[1].
CAS Number
815595-27-8
UNSPSC
12352005
Target
P38 MAPK
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Smiles
FC1=CC=C(C2=C(C3=CC=NC(NC4CCNCC4)=N3)N5C=COC5=N2)C=C1
Molecular Formula
C20H19FN6O
Molecular Weight
378.40
References & Citations
[1]Ashwell M, et al., Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase. WO2006044869A1
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

p38 MAP Kinase-IN-1
CAS Number815595-27-8
PubChem CID11417587
IUPAC Name4-[6-(4-fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]-N-piperidin-4-ylpyrimidin-2-amine
Molecular FormulaC20H19FN6O
Molecular Weight378.4
XLogP3.4
Topological Polar Surface Area80.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity513
SMILES
C1CNCCC1NC2=NC=CC(=N2)C3=C(N=C4N3C=CO4)C5=CC=C(C=C5)F
InChI
InChI=1S/C20H19FN6O/c21-14-3-1-13(2-4-14)17-18(27-11-12-28-20(27)26-17)16-7-10-23-19(25-16)24-15-5-8-22-9-6-15/h1-4,7,10-12,15,22H,5-6,8-9H2,(H,23,24,25)
InChIKey
MGNQNQOSSLCUFP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of p38 MAP Kinase-IN-1
CAS: 815595-27-8
CID: 11417587
Formula: C20H19FN6O
MW: 378.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight378.4
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass378.16043741
Monoisotopic Mass378.16043741
Topological Polar Surface Area80.3 Ų
Heavy Atom Count28
Formal Charge0
Complexity513
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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HY-112401P38 MAP Kinase Inhibitor IV
HY-177320P38 Kinase-IN-9
HY-12839-01P38 MAPK-IN-1
HY-18874-01P38-α MAPK-IN-1
HY-171296P38 Kinase inhibitor 8
HY-171295P38 Kinase inhibitor 7

Alternative Products

CatalogName
MBS623273-01Hematopoietic Progenitor Kinase 1 (HPK1, Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAP4K1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1)
319519-01HPK1 (MAP4K1, Mitogen-activated protein kinase kinase kinase kinase 1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1)
MBS6004364-01MAP4K1 (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1)
323584MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1, EC 2.7.11.1, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1)
M3949-71BMAP4K1, CT (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1)
150067MAP4K1 (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1) discontinued
H1827-59B-PHematopoietic Progenitor Kinase 1, Control Peptide (HPK1, Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAP4K1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1) discontinued
MBS6488246-01MAP4K1, CT (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1) (AP)
MBS624216-01MAP4K1, phosphorylated (Ser171) (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1)
M3949-71B-APCMAP4K1, CT (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1) (APC)

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