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P38 MAP Kinase-IN-3

CAT: 0804-HY-178209Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178209Size:1 Each
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Description
P38 MAP Kinase-IN-3 is a p38 MAP kinase inhibitor (IC50 = 0.09 µM) . p38 MAP Kinase-IN-3 can be used for research on metabolic conditions[1].
CAS Number
384820-17-1
UNSPSC
12352005
Target
P38 MAPK
Related Pathways
MAPK/ERK Pathway
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
FC1=CC=C(C2=C(C3=CC=NC=C3)N=C(C4=C(Br)C=CC=C4)N2)C=C1
Molecular Formula
C20H13BrFN3
Molecular Weight
394.24
References & Citations
[1]Chang LL, et al. Substituted imidazoles as glucagon receptor antagonists. Bioorg Med Chem Lett. 2001 Sep 17;11 (18) :2549-53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-[2-(2-bromophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]Pyridine
CAS Number384820-17-1
PubChem CID9886904
IUPAC Name4-[2-(2-bromophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine
Molecular FormulaC20H13BrFN3
Molecular Weight394.2
XLogP4.8
Topological Polar Surface Area41.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity423
SMILES
C1=CC=C(C(=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)Br
InChI
InChI=1S/C20H13BrFN3/c21-17-4-2-1-3-16(17)20-24-18(13-5-7-15(22)8-6-13)19(25-20)14-9-11-23-12-10-14/h1-12H,(H,24,25)
InChIKey
COVWDRBCMJOSQM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[2-(2-bromophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]Pyridine
CAS: 384820-17-1
CID: 9886904
Formula: C20H13BrFN3
MW: 394.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight394.2
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass393.02769
Monoisotopic Mass393.02769
Topological Polar Surface Area41.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity423
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
222956-01GLK (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3, MAPK/ERK Kinase Kinase Kinase 3, MEK Kinase Kinase 3, Germinal center Kinase Related Protein Kinase, MEKKK 3, MAP4K3) discontinued
406686-01MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3, Germinal Center Kinase-Related Protein Kinase, GLK, MAPK/ERK Kinase Kinase Kinase 3, MEK Kinase Kinase 3, MEKKK 3, RAB8IPL1)
129569MEKK3 (MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, Mitogen-activated Protein Kinase Kinase Kinase 3, MAP3K3, MAPKKK3)
323550-01MAP3K3 (MAPKKK3, MEKK3, Mitogen-activated protein kinase kinase kinase 3, MAPK/ERK kinase kinase 3, MEK kinase 3, MEKK 3)
317268-01GLK, NT (MAP4K3, RAB8IPL1, Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Germinal Center Kinase-related Protein Kinase, MAPK/ERK Kinase Kinase Kinase 3, MEK Kinase Kinase 3, MEKKK 3)
224106-01MEK Kinase (Mitogen-Activated Protein Kinase Kinase Kinase 3, MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, MAP3K3, MAPKKK3, MEKK3) discontinued
G3025-90CGLK, CT (Germinal Center Kinase Related Protein Kinase, Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, MAP4K3, MAPKKKK3, MAPK/ERK Kinase Kinase Kinase 3, MEK Kinase Kinase 3, MEKKK 3, RAB8IPL1)
129571-FITCMEKK3 (MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, Mitogen-activated Protein Kinase Kinase Kinase 3, MAP3K3, MAPKKK3) (FITC)
129571-PEMEKK3 (MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, Mitogen-activated Protein Kinase Kinase Kinase 3, MAP3K3, MAPKKK3) (PE)
129571-BiotinMEKK3 (MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, Mitogen-activated Protein Kinase Kinase Kinase 3, MAP3K3, MAPKKK3) (Biotin)

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