Products for Research Use Only
RegisterLogin

SGK1-IN-6

CAT: 0804-HY-170933Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-170933Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SGK1-IN-6 (compound 12f) is a potent SGK1 inhibitor with an IC50 of 0.39 μM. SGK1-IN-6 suppresses tumor growth in the PC3 xenograft model in BALB/c nude mice without inducing any observable toxicity[1].
CAS Number
3046378-98-4
UNSPSC
12352005
Target
SGK
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C1=CC2=C(C(F)(F)F)C=C(NC3=CC=C(N4CCNCC4)C=C3OC)N=C2C=C1OC)NC5=CC=C(C=C5)OC
Molecular Formula
C30H30F3N5O4
Molecular Weight
581.59
References & Citations
[1]T Li C, et al. Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity. Eur J Med Chem. 2025 Apr 5;287:117336.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SGK1

Chemical Information

Sgk1-IN-6
CAS Number3046378-98-4
PubChem CID173640858
IUPAC Name7-methoxy-N-(4-methoxyphenyl)-2-(2-methoxy-4-piperazin-1-ylanilino)-4-(trifluoromethyl)quinoline-6-carboxamide
Molecular FormulaC30H30F3N5O4
Molecular Weight581.6
XLogP5.2
Topological Polar Surface Area97
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count8
Heavy Atom Count42
Formal Charge0
Complexity870
SMILES
COC1=CC=C(C=C1)NC(=O)C2=C(C=C3C(=C2)C(=CC(=N3)NC4=C(C=C(C=C4)N5CCNCC5)OC)C(F)(F)F)OC
InChI
InChI=1S/C30H30F3N5O4/c1-40-20-7-4-18(5-8-20)35-29(39)22-15-21-23(30(31,32)33)16-28(37-25(21)17-26(22)41-2)36-24-9-6-19(14-27(24)42-3)38-12-10-34-11-13-38/h4-9,14-17,34H,10-13H2,1-3H3,(H,35,39)(H,36,37)
InChIKey
LUUSQGGJIVYGID-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sgk1-IN-6
CAS: 3046378-98-4
CID: 173640858
Formula: C30H30F3N5O4
MW: 581.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight581.6
XLogP35.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count8
Exact Mass581.22498894
Monoisotopic Mass581.22498894
Topological Polar Surface Area97 Ų
Heavy Atom Count42
Formal Charge0
Complexity870
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-142687-01SGK1-IN-4
HY-135893-01SGK1-IN-2
HY-18607-01SGK1-IN-1
HY-128221-01SGK1-IN-5
HY-142686SGK1-IN-3
HY-142686A-01SGK1-IN-3 (hydrochloride)
HY-P85758SGK1 Antibody (YA5450, Mouse)
HY-P81780-01SGK1 Antibody (YA1525, Rabbit)
HY-RS12800Sgk1 Rat Pre-designed siRNA Set A
HY-RS12798SGK1 Human Pre-designed siRNA Set A

Alternative Products

CatalogName
T205289-01SGK1-IN-6
334086-01SGK1
GTR18898058-01SGK1 peptide
GTR18126650SGK1 Antibody
BA8346-10SGK1-IN-2
T12890SGK1-IN-1
334085SGK1 discontinued
576174-01SGK1 (Biotin)
MBS515659-01SGK1, Active

Popular Products