SGK1-IN-3 (hydrochloride)

• UNSPSC Description:

  SGK1-IN-3 hydrochloride (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride has the potential for the research of osteoarthritis[1].

• Target Antigen:

  SGK

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/sgk1-in-3-hydrochloride.html

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC(C2=CC=C(C=C2)NS(=O)(C3=C(C(Cl)=CC=C3)Cl)=O)=NC4=C1C=NN4)N[C@@H]5CCNC5.[H]Cl

• Molecular Weight:

  567.88

• References & Citations:

  [1]Halland N, et al. Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J Med Chem. 2022;65(2):1567-1584.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported