BKCa activator-1

• Description:

  BKCa activator-1 (Compound 51b) is the orally active activator for the calcium-activated potassium channel BKCa with an EC50 of 2.82 μM. BKCa activator-1 increases K+ efflux, leads to cell membrane hyperpolarization, thereby inhibiting smooth muscle contraction. BKCa activator-1 alleviates urinary incontinence in spontaneously hypertensive rat (SHR) model, exhibits antitussive effect in puinea pig cough model[1].

• UNSPSC:

  12352005

• Target:

  Potassium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Others

• Smiles:

  OC1=C (C=CC (NCCCCCN2CCOCC2) =C1) OC3=C (C (F) =C (C (F) =C3F) C (F) (F) F) F

• Molecular Formula:

  C22H23F7N2O3

• Molecular Weight:

  496.42

• References & Citations:

  [1]Park SB, et al., Discovery of Diphenyl Ether Derivatives as Novel BKCa Channel Activators: Structure-Activity Relationship, Cryo-EM Complex Structures, and In Vivo Animal Studies. J Med Chem. 2025 Feb 27;68 (4) :4259-4286.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported