TIR-199

• Description:

  TIR-199 is a novel and highly specific dual proteasome inhibitor that can effectively inhibit the PSMB5 subunit of constitutive proteasome and the PSMB8 subunit of immunoproteasome. TIR-199 can induce the death of various tumor cells. TIR-199 can be used for research on myeloma[1].

• UNSPSC:

  12352005

• Target:

  Proteasome

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  CC(C)[C@H](NC(NCCCCCCCCCCCC)=O)C(N[C@@H]1C(N[C@@H](C)/C=C/C(NCC/C=C/1)=O)=O)=O

• Molecular Formula:

  C29H51N5O4

• Molecular Weight:

  533.75

• References & Citations:

  [1]Tandon V, et al. Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo. Biosci Rep. 2022 Feb 25;42 (2) :BSR20212721.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1514925-83-7]