TIR-199

• Description :

  TIR-199 is a novel and highly specific dual proteasome inhibitor that can effectively inhibit the PSMB5 subunit of constitutive proteasome and the PSMB8 subunit of immunoproteasome. TIR-199 can induce the death of various tumor cells. TIR-199 can be used for research on myeloma[1].

• UNSPSC :

  12352005

• Target :

  Proteasome

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Smiles :

  CC(C)[C@H](NC(NCCCCCCCCCCCC)=O)C(N[C@@H]1C(N[C@@H](C)/C=C/C(NCC/C=C/1)=O)=O)=O

• Molecular Formula :

  C29H51N5O4

• Molecular Weight :

  533.75

• References & Citations :

  [1]Tandon V, et al. Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo. Biosci Rep. 2022 Feb 25;42 (2) :BSR20212721.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1514925-83-7]