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TIR-199

CAT: 0804-HY-170881Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170881Size:1 Each
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Description
TIR-199 is a novel and highly specific dual proteasome inhibitor that can effectively inhibit the PSMB5 subunit of constitutive proteasome and the PSMB8 subunit of immunoproteasome. TIR-199 can induce the death of various tumor cells. TIR-199 can be used for research on myeloma[1].
CAS Number
1514925-83-7
UNSPSC
12352005
Target
Proteasome
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC(C)[C@H](NC(NCCCCCCCCCCCC)=O)C(N[C@@H]1C(N[C@@H](C)/C=C/C(NCC/C=C/1)=O)=O)=O
Molecular Formula
C29H51N5O4
Molecular Weight
533.75
References & Citations
[1]Tandon V, et al. Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo. Biosci Rep. 2022 Feb 25;42 (2) :BSR20212721.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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