PIP-199

• Description:

  PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  DNA Alkylator/Crosslinker

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pip-199.html

• Purity:

  98.0

• Solubility:

  DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  O=C (N1CCN (C (C2=C (C3=CC=CC=C3) N (O) C4=C2C=CC=C4) C5=NC=CC=C5) CC1) OCC

• Molecular Formula:

  C27H28N4O3

• Molecular Weight:

  456.54

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Andrew F. Voter, et al. A high throughput screening strategy to identify protein-protein interaction inhibitors that block the Fanconi anemia DNA repair pathway. J Biomol Screen. 2016 Jul; 21 (6) : 626–633.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  622795-76-0