STEP-IN-1

• Description :

  STEP-IN-1 (Compound 14b) is a potent and selective STEP inhibitor with an IC50 of 5.27 μM. STEP-IN-1 has a neuroprotective effect, which can protect nerve cells from glutamate-induced toxicity, reduce cellular ROS accumulation, and inhibit apoptosis. STEP-IN-1 can be used in the study of neurodegenerative diseases[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(/C1=C/C2=CC=C(O2)C3=CC=C(C=C3Cl)C(O)=O)C4=C(C=CC=C4[N+]([O-])=O)C1=O

• Molecular Formula :

  C21H10ClNO7

• Molecular Weight :

  423.76

• References & Citations :

  [1]Jiang C, et al. Design and synthesis of novel benzoic acid derivatives as striatal-enriched protein tyrosine phosphatase (STEP) inhibitors with neuroprotective properties. Eur J Med Chem. 2025 Feb 5;283:117135.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported