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NLRP3-IN-60

CAT: 0804-HY-170364Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170364Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLRP3-IN-60 (Compound 39) is the orally active inhibitor for NLRP3. NLRP3-IN-60 inhibits pyroptosis with an IC50 of 13 nM in THP-1 cell. NLRP3-IN-60 inhibits IL-1β release with an IC50 of 225 nM in human whole blood[1].
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; Pyroptosis
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
FC1=NN2C=C1S(=O)(NC(CC3=C(C4=CC(OCC2(C)C)=NC=C4)C=CC(F)=C3C(C)C)=O)=O
Molecular Formula
C23H24F2N4O4S
Molecular Weight
490.52
References & Citations
[1]Mesch S, et al., Novel Macrocyclic NLRP3 Inhibitors. J Med Chem. 2024 Dec 12;67 (23) :20911-20932.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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