PKN3-IN-1

CAT: 0804-HY-169789-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-169789-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine protein kinase 3) and GAK (cyclin G-associated kinase) with IC50 of 0.014 μM and Ki of 0.0044 μM respectively. PKN3-IN-1 is a potential tool compound to study the cell biology of PKN3 and its role in pancreatic and prostate cancer and T-cell acute lymphoblastic leukemia [1].
CAS Number
[2361545-75-5]
UNSPSC
12352005
Target
PI3K
Related Pathways
PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Purity
98.97
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; adjust pH to 3 with 1 M HCl; heat to 60°C)
Smiles
IC1=CC2=NC=CC(NC3=CC(OC)=C(C(OC)=C3)OC)=C2C=C1
Molecular Formula
C18H17IN2O3
Molecular Weight
436.24
References & Citations
[1]Asquith CRM, et al. Identification of 4-Anilinoquin (az) oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype. ChemMedChem. 2022 Jun 20;17 (12) :e202200161.|[2]Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018 Jan 8;13 (1) :48-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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