PD 404182 (Standard)

• Description:

  Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1].

• UNSPSC:

  12352005

• Target:

  Antibiotic; Dimethylargininase (DDAH) ; Reference Standards

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling; Others

• Field of Research:

  Inflammation/Immunology

• Smiles:

  N=C1SC2=CC=CC=C2C3=NCCCN13

• Molecular Formula:

  C11H11N3S

• Molecular Weight:

  217.29

• References & Citations:

  [1]Ghebremariam YT, et, al. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J Pharmacol Exp Ther. 2014 Jan; 348 (1) : 69-76.|[2]Chamoun-Emanuelli AM, et, al. Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob Agents Chemother. 2014; 58 (2) : 687-97.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [72596-74-8]