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PD 404182 (Standard)

CAT: 0804-HY-16958RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16958RSize:1 Each
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Description
Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1].
CAS Number
72596-74-8
UNSPSC
12352005
Target
Antibiotic; Dimethylargininase (DDAH) ; Reference Standards
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Inflammation/Immunology
Smiles
N=C1SC2=CC=CC=C2C3=NCCCN13
Molecular Formula
C11H11N3S
Molecular Weight
217.29
References & Citations
[1]Ghebremariam YT, et, al. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J Pharmacol Exp Ther. 2014 Jan; 348 (1) : 69-76.|[2]Chamoun-Emanuelli AM, et, al. Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob Agents Chemother. 2014; 58 (2) : 687-97.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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