RegisterLogin

LA-CB1

CAT: 0804-HY-168996-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-168996-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
LA-CB1 is an Abemaciclib (HY-16297A) derivative that targets CDK4/6 and promotes its degradation via the ubiquitin-proteasome pathway, thereby disrupting the CDK4/6-Cyclin D1-Rb-E2F axis and inducing G0/G1 cell cycle arrest and apoptosis. LA-CB1 exhibits antiproliferative activity against MDA-MB-231 cells, with an IC50 of 0.27 µM, and effectively inhibits epithelial-mesenchymal transition (EMT), cell migration, invasion, and angiogenesis. In highly aggressive models such as triple-negative breast cancer (TNBC), LA-CB1 significantly suppresses tumor growth in a dose-dependent manner. LA-CB1 holds potential for research in the field of breast cancer[1].
CAS Number
[3032908-44-1]
UNSPSC
12352005
Target
Apoptosis; CDK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Concentration
10mM
Purity
98.20
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=NC2=C(C=C(C=C2N1C(C)C)C3=CC=NC(NC4=CC(Cl)=C(C=C4)OCC5=C(C=CC=N5)C#N)=N3)F
Molecular Formula
C28H23ClFN7O
Molecular Weight
527.98
References & Citations
[1]He J, et al. Targeted degradation of CDK4/6 by LA-CB1 inhibits EMT and suppresses tumor growth in orthotopic breast cancer. Sci Rep. 2025 Mar 4;15 (1) :7605.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6

Related Products

CatalogName
HY-174838CB1-IN-3
HY-12790-01CB1-IN-1
HY-147821CB1-IN-2
HY-120653-01CB1 antagonist 5
HY-U00397CB1 antagonist 1
HY-178857CB1 antagonist 6
HY-148137-01CB1 agonist 1
HY-116649-01CB1 antagonist 2
HY-112340-01CB1 antagonist 4
HY-146133LA-Bac8c

Alternative Products

CatalogName
T206483-01LA-CB1
309444-01CB1
MBS3601811-01CB1-IN-4
RQ4287CB1 Antibody
T61609-01CB1-IN-2
BA5215-25CB1-IN-1
T210564-01CB1-IN-3
sc-293419CB1 (2F9)
386900CB1 discontinued
P510691CB1 Protein ()

Popular Products