LA-CB1

• Target:

  CDK|||Apoptosis

• Related Pathways:

  Apoptosis|||Cell Cycle/Checkpoint

• Bioactivity:

  LA-CB1 is a derivative of Abemaciclib that targets CDK4/6 and promotes their degradation via the ubiquitin-proteasome pathway, thereby blocking the CDK4/6-Cyclin D1-Rb-E2F axis and inducing G0/G1 cell cycle arrest and apoptosis (Apoptosis) . It demonstrates antiproliferative activity against MDA-MB-231 cells with an IC50 of 0.27 µM and effectively inhibits epithelial-mesenchymal transition, cell migration, invasion, and angiogenesis. In highly invasive models like triple-negative breast cancer (TNBC), LA-CB1 significantly suppresses tumor growth, showing robust dose-dependent antitumor activity. This compound can be utilized in breast cancer research.

• Smiles:

  N#CC1=CC=CN=C1COC2=CC=C(C=C2Cl)NC=3N=CC=C(N3)C=4C=C(F)C=5N=C(N(C5C4)C(C)C)C

• Molecular Formula:

  C28H23ClFN7O

• Molecular Weight:

  527.98

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3032908-44-1