Antibacterial agent 261

• Description:

  Antibacterial agent 261 (compound 43) is a potent inhibitor of peptidomimetic peptide deformylase (PDF), with IC50 of 2.5 and 10.6 nM for S. aureus and E. coli, respectively[1].

• UNSPSC:

  12352005

• Target:

  Bacterial

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  O=C([C@H](CCCC)CN(C=O)O)N1CCC[C@H]1C2=NN=C(C3=CC=CS3)S2

• Molecular Formula:

  C18H24N4O3S2

• Molecular Weight:

  408.54

• References & Citations:

  [1]Shouning Yang, et al. Design, Synthesis, and Biological Evaluation of 1,3,4-Thiadiazole Derivatives as Novel Potent Peptide Deformylase Inhibitors for Combating Drug-Resistant Gram-Positive and -Negative Bacteria. J Med Chem. 2025 Jan 7. doi: 10.1021/acs.jmedchem.4c02177

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3036109-97-1]