Antibacterial agent 119

• Description :

  Antibacterial agent 119 (Compound 21 g) is an antibacterial candidate against Methicillin (HY-121544) -resistant Staphylococcus aureus (MICs less than 1 μg/mL against tested strains) . Antibacterial agent 119 induces ROS production. Antibacterial agent 119 also acts on the bacterial cell membrane to cause membrane breakage. Antibacterial agent 119 exhibits potent antibacterial activity with low cytotoxicity, rapid bactericidal ability, and good in vivo antibacterial activity[1].

• UNSPSC :

  12352005

• Target :

  Bacterial; Reactive Oxygen Species (ROS)

• Related Pathways :

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Infection

• Smiles :

  C[C@@]12[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](CCC5=[N+](CC6=CC=C(Cl)C=C6)C=CC7=C5NC8=C7C=C(OC)C=C8)C)([H])C[C@H](O)CC1.[Br-]

• Molecular Formula :

  C42H54BrClN2O4

• Molecular Weight :

  766.25

• References & Citations :

  [1]Huo H, et al. Novel steroidal β-carboline derivatives as promising antibacterial candidates against methicillin-resistant Staphylococcus aureus. Eur J Med Chem. 2025 Feb 5;283:117187.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported