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PARP1-IN-35

CAT: 0804-HY-168851Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168851Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PARP1-IN-35 (compound T26) is a selective, orally active, cross -the blood-brain barrierPARP1 inhibitor with IC50 values of 0.2, 122 nM for PARP1, PARP2, respectively. PARP1-IN-35 shows antiproliferative activity and anticancer activity. PARP1-IN-35 has the potential for the research of breast cancer[1].
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C1NC2=C(C=C1CC)N=CC(CN3CC=C(CC3)C4=CC=C(C=N4)C#N)=C2
Molecular Formula
C22H21N5O
Molecular Weight
371.44
References & Citations
[1]Guo T, et al. Design, Synthesis, and Pharmacodynamic Evaluation of Highly Selective PARP1 Inhibitors with Brain Penetrance. J Med Chem. 2025 Jan 10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2

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