PARP1-IN-35

• Description :

  PARP1-IN-35 (compound T26) is a selective, orally active, cross -the blood-brain barrierPARP1 inhibitor with IC50 values of 0.2, 122 nM for PARP1, PARP2, respectively. PARP1-IN-35 shows antiproliferative activity and anticancer activity. PARP1-IN-35 has the potential for the research of breast cancer[1].

• UNSPSC :

  12352005

• Target :

  PARP

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Field of Research :

  Cancer

• Smiles :

  O=C1NC2=C(C=C1CC)N=CC(CN3CC=C(CC3)C4=CC=C(C=N4)C#N)=C2

• Molecular Formula :

  C22H21N5O

• Molecular Weight :

  371.44

• References & Citations :

  [1]Guo T, et al. Design, Synthesis, and Pharmacodynamic Evaluation of Highly Selective PARP1 Inhibitors with Brain Penetrance. J Med Chem. 2025 Jan 10.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PARP1; PARP2