PPI-4955

CAT: 0804-HY-16621Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-16621Size:1 Each
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Description
PPI-4955 is a subtype 1 (S1P₁) agonist of sphingosine-1-phosphate receptor with an EC50 of 1.62 nM. PPI-4955-P (the active phosphorylated form) exhibits excellent receptor selectivity and affinity, and the IC50 values for hS1P₁, hS1P₃, hS1P₄, and hS1P₅ are 0.23, 2000, 6.5, and 184 nM respectively. PPI-4955 has significantly improved in vivo phosphorylation efficiency, which can reduce lymphocytes and improve cardiovascular risk. PPI-4955 can be used in immunomodulation research[1].
CAS Number
[911412-31-2]
UNSPSC
12352005
Target
SphK
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
C[C@@](CO)(N)C1=NC=C(N1)C2=CC(C(F)(F)F)=C(OCC3=CC=C(C4=CC=CC=C4)C=C3)C=C2
Molecular Formula
C26H24F3N3O2
Molecular Weight
467.48
References & Citations
[1]Evindar G, et al. Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists. Bioorg Med Chem Lett. 2010 Apr 15;20 (8) :2520-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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