PPI-2458

• Target :

  Others|||Aminopeptidase

• Related Pathways :

  Others|||Metabolism

• Bioactivity :

  PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class.

• Smiles :

  C[C@@]1([C@@]2([C@@]3(CO3)CC[C@@H](OC(N[C@H]([C@@H](C)C)C(N)=O)=O)[C@H]2OC)[H])[C@@H](CC=C(C)C)O1

• Molecular Formula :

  C22H36N2O6

• Molecular Weight :

  424.53

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  431077-35-9