PEX5-PEX14 PPI-IN-1

• UNSPSC Description:

  PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 PPI inhibitor. PEX5-PEX14 PPI-IN-1 disrupts the PEX5-TbPEX14 PPI with a Ki of 53 μM. PEX5-PEX14 PPI-IN-1 inhibits the bloodstream form of T. b. brucei (EC50: 5 μM)[1].

• Target Antigen:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/pex5-pex14-ppi-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC)[C@@H](N1C([C@H](CC2=CNC3=C2C=CC=C3)NCCC1)=O)CC4=CNC5=C4C=CC=C5

• Molecular Weight:

  444.53

• References & Citations:

  [1]Marciniak M, et al. Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template. Eur J Med Chem. 2023 Oct 5;258:115587.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported