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MCB-36

CAT: 0931-T212089-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212089-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PERK, Apoptosis, PROTACs, Caspase, p38 MAPK, Ras, TNF
Related Pathways
Proteases/Proteasome, PROTAC, Apoptosis, MAPK
Bioactivity
MCB-36 is a versatile KRAS-targeting PROTAC degrader recruiting the VHL protein without affecting KRAS transcription. It exerts minimal impact on HRAS and NRAS protein levels. MCB-36 binds with high affinity (Kd ≈ 1 pM) to G12D, G12C, G12V, and wild-type KRAS in the GDP-loaded state. By reducing p-ERK levels, MCB-36 induces apoptosis (apoptosis) . It effectively inhibits cancer cells resistant to KRASG12C and remodels the tumor immune microenvironment. MCB-36 is applicable in research on colorectal and lung cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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