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SCH-900875

CAT: 0804-HY-165428-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-165428-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SCH-900875 is an orally active, brain-penetrant and selective CXCR3 receptor inhibitor, which also shows high selectivity over CXCR1 and CXCR2 receptors. SCH-900875 binds to CXCR3, blocking the binding of ligands CXCL9, CXCL10, and CXCL11, inhibiting downstream G protein and β-arrestin signaling pathways to suppress inflammatory cell migration. SCH-900875 is promising for research of autoimmune diseases (rheumatoid arthritis, multiple sclerosis) and inflammatory disorders (psoriasis, inflammatory bowel disease) [1][2].
CAS Number
907206-98-8
UNSPSC
12352005
Target
Arrestin; CXCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Purity
98.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(Cl)C=C1)N2CCC(N3[C@@H](CC)CN(C4=NC=C(C5=NN=C(NCC)O5)N=C4C)[C@H](C)C3)CC2
Molecular Formula
C28H37ClN8O2
Molecular Weight
553.10
References & Citations
[1]Frank Xing Chen, et al. Process and intermediates for the Synthesis of heterocyclic Substituted Piperazines with CXCR3 Antagonist Activity. US20110124867A1. 2011-05-26.|[2]Andrews SP, Cox RJ. Small Molecule CXCR3 Antagonists. J Med Chem. 2016 Apr 14;59 (7) :2894-917.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR1; CXCR2; CXCR3

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