NIR-BG2

CAT: 0804-HY-165424Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-165424Size:1 Each
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Description
NIR-BG2 is a near-infrared fluorescent probe targeting senescence-associated β-galactosidase (SA-β-Gal) . NIR-BG2 is activated by SA-β-Gal and undergoes hydrolysis to release electrophilic quinone methide that covalently binds to surrounding proteins for in situ labeling, with a 16-fold enhancement of fluorescence signal at 709 nm . NIR-BG2 is promising for research of vivo imaging of cellular senescence[1][2].
CAS Number
[3036456-18-2]
UNSPSC
12352005
Target
Fluorescent Dye; Glycosidase
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Smiles
CCC[N+]1=C(/C=C/C2=C3C(CCC2)=CC4=CC(C(F)F)=C(OCC5=CC=C(C=C5)O[C@@H]6O[C@@H]([C@@H]([C@@H]([C@H]6O)O)O)CO)C=C4O3)C(C)(C)C7=CC=CC=C17
Molecular Formula
C42H46F2NO8+
Molecular Weight
730.81
References & Citations
[1]Liu J, et al. Noninvasive NIR Imaging of Senescence viaIn Situ Labeling. J Med Chem. 2021 Dec 23;64 (24) :17969-17978.|[2]Liu J, et al. A self-immobilizing NIR probe for non-invasive imaging of senescence[J]. BioRxiv, 2020: 2020.03. 27.010827.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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