Auristatin S

• Description:

  Auristatin S is an Auristatin payload with potent antitumor activity. Auristatin S attenuates bystander activity with improved off-target toxicity. Auristatin S has excellent tolerability in Karpas/KarpasBVR cell models. Auristatin S can be used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types[1].

• UNSPSC:

  12352005

• Target:

  ADC Payload; Microtubule/Tubulin

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

• Field of Research:

  Cancer

• Smiles:

  CC[C@@H]([C@H](N(C([C@H](C(C)C)NC([C@H](CO)N(C)C)=O)=O)C)[C@H](OC)CC(N1CCC[C@H]1[C@@H]([C@@H](C)C(N[C@@H](CC2=CC=CC=C2)CO)=O)OC)=O)C

• Molecular Formula:

  C38H65N5O8

• Molecular Weight:

  719.95

• References & Citations:

  [1]Moquist PN, et al. Auristatin S: An Auristatin Payload with Improved Tolerability and Modified Bystander Activity. ACS Med Chem Lett. 2025 Jun 23;16 (7) :1354-1358.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3028453-70-2]