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Auristatin S

CAT: 0804-HY-164107Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164107Size:1 Each
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Description
Auristatin S is an Auristatin payload with potent antitumor activity. Auristatin S attenuates bystander activity with improved off-target toxicity. Auristatin S has excellent tolerability in Karpas/KarpasBVR cell models. Auristatin S can be used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types[1].
CAS Number
3028453-70-2
UNSPSC
12352005
Target
ADC Payload; Microtubule/Tubulin
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
CC[C@@H]([C@H](N(C([C@H](C(C)C)NC([C@H](CO)N(C)C)=O)=O)C)[C@H](OC)CC(N1CCC[C@H]1[C@@H]([C@@H](C)C(N[C@@H](CC2=CC=CC=C2)CO)=O)OC)=O)C
Molecular Formula
C38H65N5O8
Molecular Weight
719.95
References & Citations
[1]Moquist PN, et al. Auristatin S: An Auristatin Payload with Improved Tolerability and Modified Bystander Activity. ACS Med Chem Lett. 2025 Jun 23;16 (7) :1354-1358.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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