Sumatriptan (succinate) (Standard)

• Description :

  Sumatriptan (succinate) (Standard) is the analytical standard of Sumatriptan (succinate) . This product is intended for research and analytical applications. Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research[1][2].

• CAS Number :

  [103628-48-4]

• Product Name Alternative :

  GR 43175 succinate (Standard)

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Reference Standards

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/sumatriptan-succinate-standard.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)CCC(O)=O.O=S(CC1=CC2=C(NC=C2CCN(C)C)C=C1)(NC)=O

• Molecular Formula :

  C18H27N3O6S

• Molecular Weight :

  413.49

• References & Citations :

  [1]Razzaque Z, et al. Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. Br J Clin Pharmacol. 1999 Jan;47 (1) :75-82.|[2]S J Peroutka, et al. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163 (1) :133-6. |[3]Bates EA, et al. Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia. 2010 Feb;30 (2) :170-8.|[4]K L Dechant, et al. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992 May;43 (5) :776-98.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• Clinical Information :

  Launched

• Isoform :

  5-HT1 Receptor