Wnt/β-catenin-IN-3

• UNSPSC Description:

  Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI50s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of p53-p21 pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells[1].

• Target Antigen:

  MDM-2/p53; Wnt; β-catenin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/wnt-β-catenin-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C(C=C1)C(NC2=CC(C3=CC(C4=C(C(OC)=C(C=C4O3)OC)OC)=O)=CC=C2)=O

• Molecular Weight:

  461.46

• References & Citations:

  [1]Hassan AHE, et al. Discovery of a stilbenoid-flavanone hybrid as an antitumor Wnt/β-catenin signaling pathway inhibitor. Bioorg Chem. 2024 Apr;145:107178.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1809413-98-6