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Vortioxetine-d3

CAT: 804-HY-15414S3Size: 1 EachDry Ice: NoHazardous: No
1 EachSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vortioxetine-d3 (Lu AA 21004-d3) is a deuterium labeled Vortioxetine (HY-15414) . Vortioxetine (Lu AA 21004) is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial agonist of 5-HT1B (Ki: 15 nM, 33 nM) [1][2].
CAS Number
[1629684-22-5]
Product Name Alternative
Lu AA 21004-d3
UNSPSC
12352005
Target
5-HT Receptor; Isotope-Labeled Compounds; Serotonin Transporter
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
[2H]C([2H])([2H])C1=CC(C)=C(SC2=C(N3CCNCC3)C=CC=C2)C=C1
Molecular Formula
C18H19D3N2S
Molecular Weight
301.46
References & Citations
[1]Bang-Andersen B, et al. Discovery of 1-[2- (2,4-dimethylphenylsulfanyl) phenyl]piperazine (Lu AA21004) : a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54 (9) :3206-21.|[2]Guilloux JP, et al. Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013 May 28;73C:147-159.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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