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Vortioxetine-d4

CAT: 0804-HY-15414S2Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15414S2Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vortioxetine-d4 (Lu AA 21004-d4) is the deuterium labeled Vortioxetine. Vortioxetine is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial agonist of 5-HT1B (Ki: 15 nM, 33 nM)[2].
Product Name Alternative
Lu AA 21004-d4
UNSPSC
12352005
Target
5-HT Receptor; Isotope-Labeled Compounds; Serotonin Transporter
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
[2H]C(NC([2H])([2H])C1)([2H])CN1C(C=CC=C2)=C2SC3=CC=C(C)C=C3C
Molecular Formula
C18H18D4N2S
Molecular Weight
302.47
References & Citations
[1]Bang-Andersen B, et al. Discovery of 1-[2- (2,4-dimethylphenylsulfanyl) phenyl]piperazine (Lu AA21004) : a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54 (9) :3206-21.|[2]Guilloux JP, et al. Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013 May 28;73C:147-159.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT3 Receptor;5-HT7 Receptor

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