BBT

• Description :

  BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS) . BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ (HY-13753) ) -induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway[1].

• UNSPSC :

  12352005

• Target :

  Calcium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/bbt.html

• Purity :

  99.71

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  C1(=CC=C(Br)S1)C(=O)NC1=CC=CC=C1C(C1C=CC=CC=1)=O

• Molecular Formula :

  C18H12BrNO2S

• Molecular Weight :

  386.27

• References & Citations :

  [1]Yao XG, et al. BBT improves glucose homeostasis by ameliorating -cell dysfunction in type 2 diabetic mice. J Endocrinol. 2015 Mar;224 (3) :327-41.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Dedicated for Diverse Library

• Clinical Information :

  No Development Reported

• CAS Number :

  [445000-45-3]