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NG 52 (Standard)

CAT: 0804-HY-15154R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15154R-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NG 52 (Standard) is the analytical standard of NG 52. This product is intended for research and analytical applications. NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p[1][2].
CAS Number
212779-48-1
UNSPSC
12352100
Target
CDK; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
ClC1=CC(NC2=NC(NCCO)=NC3=C2N=CN3C(C)C)=CC=C1
Molecular Formula
C16H19ClN6O
Molecular Weight
346.81
References & Citations
[1]ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281 (5376) :533-8.|[2]Wen-Liang Wang, et al. Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52. Acta Pharmacol Sin. 2020 Jul 31.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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