NG 52

• Description :

  NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p[1][2].

• CAS Number :

  [212779-48-1]

• Product Name Alternative :

  Compound 52

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  CDK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/NG-52.html

• Purity :

  99.88

• Solubility :

  DMSO : 75 mg/mL (ultrasonic)

• Smiles :

  ClC1=CC(NC2=NC(NCCO)=NC3=C2N=CN3C(C)C)=CC=C1

• Molecular Formula :

  C16H19ClN6O

• Molecular Weight :

  346.81

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281 (5376) :533-8.|[2]Wen-Liang Wang, et al. Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52. Acta Pharmacol Sin. 2020 Jul 31.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK1; CDK5