NG 52

• Description:

  NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p[1][2].

• Product Name Alternative:

  Compound 52

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/NG-52.html

• Purity:

  99.88

• Solubility:

  DMSO : 75 mg/mL (ultrasonic)

• Smiles:

  ClC1=CC(NC2=NC(NCCO)=NC3=C2N=CN3C(C)C)=CC=C1

• Molecular Formula:

  C16H19ClN6O

• Molecular Weight:

  346.81

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281 (5376) :533-8.|[2]Wen-Liang Wang, et al. Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52. Acta Pharmacol Sin. 2020 Jul 31.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK1; CDK5

• CAS Number:

  [212779-48-1]