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Butyzamide (GMP)

CAT: 0804-HY-148748G-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148748G-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Butyzamide (GMP) is Butyzamide produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of platelets in mouse xenotransplantation assay[1].
CAS Number
1110767-45-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
JAK; p38 MAPK; STAT
Related Pathways
Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cardiovascular Disease
Smiles
CCCOC(C(C)(C)C)C1=CC=CC(C2=CSC(NC(C3=CC(Cl)=C(/C=C(C(O)=O)\C)C(Cl)=C3)=O)=N2)=C1OC
Molecular Formula
C29H32Cl2N2O5S
Molecular Weight
591.55
Precautions
H315, H319, H335
References & Citations
[1]Nogami W, et al. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica. 2008 Oct;93 (10) :1495-504.
Shipping Conditions
Blue Ice
Storage Conditions
Keep sealed and protect from light, store at 2-8°C
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

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