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Butyzamide

CAT: 0804-HY-148748-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148748-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of platelets in mouse xenotransplantation assay[1].
CAS Number
1110767-45-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
JAK; p38 MAPK; STAT
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/butyzamide.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCOC(C(C)(C)C)C1=CC=CC(C2=CSC(NC(C3=CC(Cl)=C(/C=C(C(O)=O)\C)C(Cl)=C3)=O)=N2)=C1OC
Molecular Formula
C29H32Cl2N2O5S
Molecular Weight
591.55
Precautions
H315, H319, H335
References & Citations
[1]Nogami W, et al. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica. 2008 Oct;93 (10) :1495-504.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2; STAT3; STAT5

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