Tafamidis (Standard)

CAT: 0804-HY-14852R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14852R-01Size:5 mg
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Description
Tafamidis (Standard) is the analytical standard of Tafamidis. This product is intended for research and analytical applications. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis[1].
CAS Number
[594839-88-0]
UNSPSC
12352100
Target
Endoplasmic Reticulum Oxidoreductase 1 (ERO1) ; Reference Standards
Related Pathways
Anti-infection; Others
Field of Research
Neurological Disease
Smiles
O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O
Molecular Formula
C14H7Cl2NO3
Molecular Weight
308.12
References & Citations
[1]Bulawa, C.E., et al., Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A, 2012. 109 (24) : p. 9629-34.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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