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Tafamidis

CAT: 0804-HY-14852-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14852-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis[1].
CAS Number
594839-88-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endoplasmic Reticulum Oxidoreductase 1 (ERO1)
Type
Reference compound
Related Pathways
Anti-infection
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tafamidis.html
Purity
99.89
Solubility
DMSO : 37.5 mg/mL (ultrasonic) |Ethanol : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O
Molecular Formula
C14H7Cl2NO3
Molecular Weight
308.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Bulawa, C.E., et al., Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A, 2012. 109 (24) : p. 9629-34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
J Med Chem. 2021 Oct 14;64 (19) :14344-14357.|Vascul Pharmacol. 2024 Jul 17:107411.

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