DDO-6600

CAT: 0804-HY-147125Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147125Size:1 Each
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Description
DDO-6600 is a covalent Hsp90 inhibitor. DDO-6600 disrupts the interaction between Hsp90 and its co-chaperone protein Cdc37, thereby inducing the degradation of kinase client proteins (such as AKT, CDK4, c-Raf) . DDO-6600 has inhibitory activity against various cancer cells. DDO-6600 inhibits the migration and invasion of HCT-116 cells, and induces cell cycle arrest and apoptosis. DDO-6600 significantly inhibits tumor growth in the HCT-116 xenograft tumor model. DDO-6600 can be used for research on colorectal cancer[1].
CAS Number
[2640292-37-9]
UNSPSC
12352005
Target
Akt; Apoptosis; CDK; HSP; Raf
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(N1C(CCCC1)C(N)=O)/C=C/C2=CN(C3=CC=CC=C3)N=C2C4=CC(C)=C(C=C4)C
Molecular Formula
C26H28N4O2
Molecular Weight
428.53
References & Citations
[1]Li L, et al. Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification. Cell Chem Biol. 2021 Oct 21;28 (10) :1446-1459.e6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; CDK4; C-Raf; HSP90

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