Products for Research Use Only
RegisterLogin

JNJ-27390467

CAT: 0804-HY-14515Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14515Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JNJ-27390467 is a potent, orally active, and selective tryptase inhibitor (human β-tryptase IC50 = 3.6 nM, Ki = 3.7 nM) . JNJ-27390467 exhibits excellent selectivity over trypsin of ~5000-fold. JNJ-27390467 shows effects in animal models of airway inflammation. JNJ-27390467 can be used for allergic asthma research[1].
CAS Number
1025795-12-3
UNSPSC
12352005
Target
Ser/Thr Protease
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
NCC1=CC=C(OCC23CCN(C(C4=CC=C(C#CC5=CC=CC=C5)O4)=O)CC3)C2=C1.OC(C6=CC=CC=C6)=O
Molecular Formula
C33H30N2O5
Molecular Weight
534.60
References & Citations
[1]Costanzo MJ, et al. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. Bioorg Med Chem Lett. 2008 Mar 15;18 (6) :2114-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P991172JNJ-70218902
HY-107139-01JNJ-10229570
HY-123481-01JNJ-42253432
HY-134188-01JNJ-54717793
HY-14450-01JNJ-31020028
HY-12190-01JNJ-5207852
HY-113751-01JNJ-39393406
HY-132895JNJ-67569762
HY-118424-01JNJ-55511118
HY-110132-01JNJ-27141491

Alternative Products

CatalogName
MBS5781880JNJ-27390467
MBS131356JNJ-63533054 (JNJ63533054; JNJ 63533054)
BA6861-10JNJ-42253432
A4361-50JNJ-1661010
BA6753-5.1JNJ-61432059
BA6849-10JNJ-55308942
C4122-10JNJ-42165279
BA5559-5.1JNJ-40411813
B5553-5JNJ 10397049
B1574-10JNJ-7777120

Popular Products