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DG013A

CAT: 0804-HY-139907-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-139907-01Size:1 mg
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Description
DG013A is a phosphinic acid tripeptide mimetic inhibitor. DG013A displays significantly weak affinity for both ERAP1 (IC50=33 nM) and ERAP2 (IC50=11 nM) . DG013A can be used for the research of autoimmune disease and cancer[1].
CAS Number
[2007955-07-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dg013a.html
Solubility
10 mM in DMSO
Smiles
O=P([C@@H](N)CCC1=CC=CC=C1)(O)C[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC2=CNC3=CC=CC=C23)=O
Molecular Formula
C27H37N4O4P
Molecular Weight
512.58
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Birgit Wilding, et al. Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1. Bioorg Med Chem Lett. 2021 Jun 15;42:128050.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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